DESCRIPTION: Nutropin® [somatropin (rDNA origin) for injection] is a human growth hormone (hGH) produced by recombinant DNA technology. Nutropin has 191 amino acid residues and a molecular weight of 22,125 daltons. The amino acid sequence of the product is identical to that of pituitary-derived human growth hormone. The protein is synthesized by a specific laboratory strain of E. coli as a precursor consisting of the rhGH molecule preceded by the secretion signal from an E. coli protein. This precursor is directed to the plasma membrane of the cell. The signal sequence is removed and the native protein is secreted into the periplasm so that the protein is folded appropriately as it is synthesized.Nutropin is a highly purified preparation. Biological potency is determined using a cell proliferation bioassay. (Click Read More Below Right...)

Humatrope®:

Humatrope is the same in its chemical structure to the growth hormone that is naturally produced by the human pituitary gland. It is "man-made" (biosynthesized) through a process known as recombinant DNA technology. In the United States, Humatrope was the first commercially available "man-made" product in which the active constituent was chemically identical to growth hormone produced by the pituitary gland.

SAIZEN®:

Saizen® [somatropin (rDNA origin) for injection] is therapeutically equivalent to the natural GH produced by the body, made by recombinant DNA technology. Saizen® is indicated for the treatment of Growth Hormone deficiency in children and adults, Turner’s syndrome, chronic renal failure.

Growth Hormone treatment of GH deficient (GHD) children with Saizen® leads to accelerated growth. The overall effect of GH therapy in GHD children who respond well is that, as adults, they will be taller than they would have been if left untreated. (be sure to click read more below / right...)

DESCRIPTION:

GENOTROPIN Lyophilized Powder contains somatropin [rDNA origin], which is a polypeptide hormone of recombinant DNA origin. It has 191 amino acid residues and a molecular weight of 22,124 daltons. The amino acid sequence of the product is identical to that of human growth hormone of pituitary origin (somatropin). GENOTROPIN is synthesized in a strain of Escherichia coli that has been modified by the addition of the gene for human growth hormone. GENOTROPIN is a sterile white lyophilized powder intended for subcutaneous injection.

GENOTROPIN 1.5 mg is dispensed in a two-chamber cartridge. The front chamber contains recombinant somatropin 1.5 mg (approximately 4.5 IU), glycine 27.6 mg, sodium dihydrogen phosphate anhydrous 0.3 mg, and disodium phosphate anhydrous 0.3 mg; the rear chamber contains 1.13 mL water for injection.

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Nutropin®:

Nutropin is produced by Genentech using recombinant DNA technology and has the same amino acid sequence as human growth hormone produced naturally in the human body. Recombinant growth hormone was cloned by Genentech scientists in 1979.

ABOUT ADULT GROWTH HORMONE DEFICIENCY
Growth hormone (hGH or GH) doesn't just contribute to physical growth in children. Adults need GH, too. In adults, GH is essential to the maintenance of healthy body composition and metabolism. When an adult's body is unable to produce enough GH, he or she is said to have adult GH deficiency (AGHD).