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Human growth hormone after surgery?

Human growth hormone after surgery?

Richard Hodin | M.D., Harvard Health Letters
November 11, 2008

Question: I heard human growth hormone can help people after surgery. Is that true?

Answer: The human growth hormone (HGH) that athletes take because they believe it helps them recover from injuries has been used successfully in burn patients for a number of years.

The healing process from a severe burn can sometimes put the body into a hypermetabolic state that ends up tearing down muscle and other tissue. In those circumstances, injections of HGH can reverse the destructive (catabolic) processes and promote constructive (anabolic) ones.

HGH also is used to help people with short bowel syndrome, a group of digestive and related problems that afflict people who have had most of the small intestine removed.

Whether HGH helps people recover from surgery has been tested in studies of orthopedic and liver patients. The results are mixed. For example, a German group reported results of a study in 2007 involving a few more than 400 people who had broken their shin bones (tibias).

Overall, the researchers didn't find HGH treatment enhanced healing of the fractures. But when they narrowed the analysis to include just people with fractures that didn't break the skin (closed fractures), they found HGH did accelerate healing quite a bit.

It's good that research is being done. Still, if I had to make a prediction, I'd say HGH will continue to be used to promote healing in a few, special circumstances, but that it won't become a routine part of post-surgical care.

There are too many potential side effects, including high blood-sugar levels and promotion of cell growth that theoretically might result in cancer.

12 Nov 2008

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